Fab-αHFc-CL-PNU is a Fab fragment of anti-human IgG Fc specific antibody conjugated to PNU-159682 with a cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. PNU-159682, a derivative of nemorubicin, is a cytotoxic small molecule which causes cell death by intercalating DNA and inhibiting replication.. The cleavable linker connecting PNU-159682 to the antibody is stable in extracellular fluid, but can be cleaved by cathepsins upon entering cells. The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC.
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