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Anti-human IgG Fc-MMAF Antibody with Cleavable Linker

Catalog Number: AH-102-AF

αHFc-CL-MMAF is anti-human IgG Fc specific antibody conjugated to monomethyl auristatin F (MMAF) with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. Monomethyl auristatin F (MMAF) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The cleavable linker connecting MMAF to the antibody is stable in extracellular fluid, but can be cleaved by endosome cathepsins upon entering cells.