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Anti-human IgG Fc-DM1 Antibody with Non-Cleavable Linker

Catalog Number: AH-103-D1

αHFc-NC-DM1 is anti-human IgG Fc specific antibody conjugated to maytansinoid DM1 with a non-cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of human IgGs. DM1 is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The non-cleavable linker connecting DM1 to the antibody is relatively stable in extracellular fluid, but can be cleaved upon entering cells.