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Anti-human IgG Fab-MMAF Antibody with Cleavable Linker

Catalog Number: AH-122-AF

αHFab-CL-MMAF is anti-human IgG Fab-specific antibody conjugated to monomethyl auristatin F (MMAF) with a cleavable linker. The antibody portion is a polyclonal antibody (as full length IgG) which is specific to the Fab region of human IgGs. Monomethyl auristatin F (MMAF) is a cytotoxic small molecule which inhibits cell division by blocking the polymerization of tubulin. The cleavable linker connecting MMAF to the antibody is stable in extracellular fluid, but is cleaved by cathepsin in endosome once the conjugate has entered a cell via endocytosis.