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Fab Anti-Human IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

Catalog Number: AH-202-DD

Fab-αHFc-CL-DMDM is a Fab fragment of anti-human IgG Fc specific antibody conjugated to duocarmycin DM (DMDM) with a cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. Duocarmycin is a cytotoxic small molecule which causes cell death by binding to the minor groove of DNA and alkylating the adenine. The cleavable linker connecting duocarmycin to the antibody is stable in extracellular fluid, but can be cleaved by cathepsins upon entering cells. The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC.