Home  »  Products  »  Secondary Antibody-Drug Conjugates  »  Fab-αHFc-NC-AAMT


Fab Anti-Human IgG Fc-Amanitin Antibody with Non-Cleavable Linker

Catalog Number: AH-205-AM

Fab-αHFc-NC-AAMT is a Fab fragment of anti-human IgG Fc specific antibody conjugated to α-amanitin with a non-cleavable linker. The antibody portion is a polyclonal antibody Fab fragment specific to the Fc region of human IgGs. Alfa-amanitin is a cytotoxic small molecule which inhibits RNA polymerases II and III by interfering with RNA and DNA translocation. The non-cleavable linker connecting α-amanitin to the antibody is stable in extracellular fluid, but can be cleaved by unspecified mechanisms upon entering cells. The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC.