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Fab Anti-Rabbit IgG Fc-Duocarmycin DM Antibody with Cleavable Linker

Catalog Number: AO-202-DD

Fab-αOFc-CL-DMDM is a Fab fragment of anti-rabbit IgG Fc specific antibody conjugated to duocarmycin DM with a cleavable linker. The antibody portion is a polyclonal antibody which is specific to the Fc region of rabbit IgGs. Duocarmycin is a cytotoxic small molecule which causes cell death by binding to the minor groove of DNA and alkylating the adenine. The cleavable linker connecting duocarmycin to the antibody is stable in extracellular fluid, but can be cleaved by cathepsin upon entering cells. The mono-valence nature of Fab 2°ADC may have some advantage in certain applications than the full length IgG 2°ADC.