Phage display is a powerful tool to screen and select for high affinity binders from a large library. This technique has been successfully applied in the discovery and development of therapeutic antibodies and diagnostic tools. With the intention to deliver a large panel of fully human monoclonal antibodies to our customers, Moradec has designed and constructed a high quality phage-displayed human Fab library (MORAFAB), which comprises approximately 10e^9 to 10e^10 unique antibodies. The MORAFAB library is a representation of 30 fully human heavy chain frame works and 20 light chain (10 kappa and 10 lambda) frame works, which were pre-selected for their good expression level and high stabilities. The library diversity is further enhanced with the carefully designed heavy and light chain CDR3s, which enables diverse epitope coverage.
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Moradec offers the following services using the MORAFAB phage-display human Fab library:
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1. Antibody discovery program (you provide the antigens, we do the panning), with turnaround time of 4-6 weeks from antigen to lead identification.
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2. Cross-species reactivity selection (you provide the antigens, we do the cross-species panning and selection), with turnaround time of 4-8 weeks from antigen to lead identification.
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3. Affinity maturation (based upon the leads identified from the library).
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In addition to the above services, Moradec also markets/licenses the existing antibody leads identified from our internal discovery programs using the MORAFAB library.
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For more information, please see MORAFAB and contact Moradec.
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